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cyclosporine will boost the amount or effect of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.elvitegravir/cobicistat/emtricitabine/tenofovir DF boosts amounts of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.The square root of two and approximations by convergents of continued fraction